Jan 13, 2015 - mobi,and more [pdf] download concepts of genetics free| unquote books. Visual art program. Concepts of genetics 11th edition solutions. COUPON: Rent Concepts of Genetics 11th edition (915) and save up to 80% on textbook rentals and 90% on used textbooks. Get FREE 7-day. Jun 29, 2018 - Book Details Author: William S. Klug,Michael R. Cummings,Charlotte A. Spencer,Michael A. Palladino Pages: 896 Publisher: Pearson Brand: English ISBN: Publication Date: 2014-09-15 Release Date: Description Concepts of Genetics, Eleventh Edition emphasizes the fundamental.
Concepts Of Genetics 11th Edition Pdf Download Free Version
Genetics Pdf Free Download
Concepts of Genetics, Eleventh Edition emphasizes the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. The best-selling text has a strong problem-solving approach, and this edition has been extensively updated with relevant, cutting-edge coverage of emerging topics in genetics.
Note: You are purchasing a standalone product; MasteringGenetics™does not come packaged with this content. If you would like to purchase both the physical text and MasteringGenetics search for ISBN-10: 0321948475/ISBN-13: 9780321948472. That package includes ISBN-10: 0321948912/ISBN-13: 9780321948915 and ISBN-10: 0133863298/ISBN-13: 9780133863291. MasteringGenetics is not a self-paced technology and should only be purchased when required by an instructor.
Sample questions asked in the 11th edition of Concepts of Genetics:
When working out genetics problems in this and succeeding chapters, always assume that members of the P 1 generation are homozygous, unless the information or data you are given require you to do otherwise. Which of Mendel’s postulates are illustrated by the pedigree that you constructed in Problem? List and define these postulates. Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.) (a) Two normal parents have five children, four normal and one albino. (b) A normal male and an albino female have six children, all normal. (c) A normal male and an albino female have six children, three normal and three albino. (d) Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).
Thomas first discovered a potentially devastating piece of family history when he learned the medical diagnosis for his brother’s increasing dementia, muscular rigidity, and frequency of seizures. His brother, at age 49, was diagnosed with Huntington disease (HD), a dominantly inherited condition that typically begins with such symptoms around the age of 45 and leads to death in one’s early 60s. As depressing as the news was to Thomas, it helped explain his father’s suicide. Thomas, 38, now wonders what his chances are of carrying the gene for HD, leading him and his wife to discuss the pros and cons of him undergoing genetic testing. Thomas and his wife have two teenage children, a boy and a girl. If Thomas tests positive for HD, and you were one of his children, would you want to be tested?
DNA damage brought on by a variety of natural and artificial agents elicits a wide variety of cellular responses involving numerous signaling pathways. In addition to the activation of DNA repair mechanisms, there can be activation of pathways leading to apoptosis (programmed cell death) and cell-cycle arrest. Why would apoptosis and cell-cycle arrest often be part of a cellular response to DNA damage?
The identification and characterization of genes that control sex determination has been a focus of investigators working with C . elegans . As with Drosophila , sex in this organism is determined by the ratio of X chromosomes to sets of auto-somes. A diploid wild-type male has one X chromosome and a diploid wild-type hermaphrodite has two X chromosomes. Many different mutations have been identified that affect sex determination. Loss-of-function mutations in a gene called her - 1 cause an XO nematode to develop into a hermaphrodite and have no effect on XX development. (That is, XX nematodes are normal hermaphrodites.) In contrast, loss-of-function mutations in a gene called tra - 1 cause an XX nematode to develop into a male. Deduce the roles of these genes in wild-type sex determination from this information.
Describe the steps by which the p53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that p53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?
In an earlier Problems and Discussion section (see Chapter 7, Problem 33), we described CC, the cat created by nuclear transfer cloning, whereby a diploid nucleus from one cell is injected into an enucleated egg cell to create an embryo. Cattle, sheep, rats, dogs, and several other species have been cloned using nuclei from somatic cells. Embryos and adults produced by this approach often show a number of different mitochondrial defects. Explain possible reasons for the prevalence of mitochondrial defects in embryos created by nuclear transfer cloning. When the cloned cat Carbon Copy (CC) was born (see the Now Solve This question), she had black patches and white patches, but completely lacked any orange patches. The knowledgeable students of genetics were not surprised at this outcome. Starting with the somatic ovarian cell used as the source of the nucleus in the cloning process, explain how this outcome occurred. NOW SOLVE THIS CC (Carbon Copy), the first cat produced from a clone, was created from an ovarian cell taken from her genetic donor, Rainbow, a calico cat. The diploid nucleus from the cell was extracted and then injected into an enucleated egg. The resulting zygote was then allowed to develop in a petri dish, and the cloned embryo was implanted in the uterus of a surrogate mother cat, who gave birth to CC. CC’s surrogate mother was a tabby (see the photo on page 187 at the end of this chapter). Geneticists were very interested in the outcome of cloning a calico cat, because they were not certain if the cat would have patches of orange and black, just orange, or just black. Taking into account the Lyon hypothesis, explain the basis of the uncertainty. Would you expect CC to appear identical to Rainbow? Explain why or why not. HINT: This problem involves an understanding of the Lyon hypothesis. The key to its solution is to realize that the donor nucleus was from a differentiated ovarian cell of an adult female cat, which itself had inactivated one of its X chromosomes.
Note: You are purchasing a standalone product; MasteringGenetics™does not come packaged with this content. If you would like to purchase both the physical text and MasteringGenetics search for ISBN-10: 0321948475/ISBN-13: 9780321948472. That package includes ISBN-10: 0321948912/ISBN-13: 9780321948915 and ISBN-10: 0133863298/ISBN-13: 9780133863291. MasteringGenetics is not a self-paced technology and should only be purchased when required by an instructor.
Sample questions asked in the 11th edition of Concepts of Genetics:
When working out genetics problems in this and succeeding chapters, always assume that members of the P 1 generation are homozygous, unless the information or data you are given require you to do otherwise. Which of Mendel’s postulates are illustrated by the pedigree that you constructed in Problem? List and define these postulates. Albinism in humans is inherited as a simple recessive trait. For the following families, determine the genotypes of the parents and offspring. (When two alternative genotypes are possible, list both.) (a) Two normal parents have five children, four normal and one albino. (b) A normal male and an albino female have six children, all normal. (c) A normal male and an albino female have six children, three normal and three albino. (d) Construct a pedigree of the families in (b) and (c). Assume that one of the normal children in (b) and one of the albino children in (c) become the parents of eight children. Add these children to the pedigree, predicting their phenotypes (normal or albino).
Thomas first discovered a potentially devastating piece of family history when he learned the medical diagnosis for his brother’s increasing dementia, muscular rigidity, and frequency of seizures. His brother, at age 49, was diagnosed with Huntington disease (HD), a dominantly inherited condition that typically begins with such symptoms around the age of 45 and leads to death in one’s early 60s. As depressing as the news was to Thomas, it helped explain his father’s suicide. Thomas, 38, now wonders what his chances are of carrying the gene for HD, leading him and his wife to discuss the pros and cons of him undergoing genetic testing. Thomas and his wife have two teenage children, a boy and a girl. If Thomas tests positive for HD, and you were one of his children, would you want to be tested?
DNA damage brought on by a variety of natural and artificial agents elicits a wide variety of cellular responses involving numerous signaling pathways. In addition to the activation of DNA repair mechanisms, there can be activation of pathways leading to apoptosis (programmed cell death) and cell-cycle arrest. Why would apoptosis and cell-cycle arrest often be part of a cellular response to DNA damage?
The identification and characterization of genes that control sex determination has been a focus of investigators working with C . elegans . As with Drosophila , sex in this organism is determined by the ratio of X chromosomes to sets of auto-somes. A diploid wild-type male has one X chromosome and a diploid wild-type hermaphrodite has two X chromosomes. Many different mutations have been identified that affect sex determination. Loss-of-function mutations in a gene called her - 1 cause an XO nematode to develop into a hermaphrodite and have no effect on XX development. (That is, XX nematodes are normal hermaphrodites.) In contrast, loss-of-function mutations in a gene called tra - 1 cause an XX nematode to develop into a male. Deduce the roles of these genes in wild-type sex determination from this information.
Describe the steps by which the p53 gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that p53 is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?
In an earlier Problems and Discussion section (see Chapter 7, Problem 33), we described CC, the cat created by nuclear transfer cloning, whereby a diploid nucleus from one cell is injected into an enucleated egg cell to create an embryo. Cattle, sheep, rats, dogs, and several other species have been cloned using nuclei from somatic cells. Embryos and adults produced by this approach often show a number of different mitochondrial defects. Explain possible reasons for the prevalence of mitochondrial defects in embryos created by nuclear transfer cloning. When the cloned cat Carbon Copy (CC) was born (see the Now Solve This question), she had black patches and white patches, but completely lacked any orange patches. The knowledgeable students of genetics were not surprised at this outcome. Starting with the somatic ovarian cell used as the source of the nucleus in the cloning process, explain how this outcome occurred. NOW SOLVE THIS CC (Carbon Copy), the first cat produced from a clone, was created from an ovarian cell taken from her genetic donor, Rainbow, a calico cat. The diploid nucleus from the cell was extracted and then injected into an enucleated egg. The resulting zygote was then allowed to develop in a petri dish, and the cloned embryo was implanted in the uterus of a surrogate mother cat, who gave birth to CC. CC’s surrogate mother was a tabby (see the photo on page 187 at the end of this chapter). Geneticists were very interested in the outcome of cloning a calico cat, because they were not certain if the cat would have patches of orange and black, just orange, or just black. Taking into account the Lyon hypothesis, explain the basis of the uncertainty. Would you expect CC to appear identical to Rainbow? Explain why or why not. HINT: This problem involves an understanding of the Lyon hypothesis. The key to its solution is to realize that the donor nucleus was from a differentiated ovarian cell of an adult female cat, which itself had inactivated one of its X chromosomes.